To study anti-inflammatory and analgesic effect of Yaotuitong capsule on experimental rats with chemical radicular neuritis, 96 wistar rats were divided into four groups: Normal, Blank, Aspirin and Yaotuitong capsule group. Chemical radicular neuritis was duplicated by operation to simulate lumbar intervertebral disc protrusion. Then, the level of mediators of inflammation, the granuloma mass caused by stimulus was detected at 3, 7, 14 and 21 days after operation, respectively. Yaotuitong capsule significantly depressed the level of PGE_2 (P<0.01)and 5-HT(P<0.01)of the local tissue around nerve root, it also could inhibit the growth of the granuloma (P<0.05). Yaotuitong capsule has the anti-inflammatory and analgesic effect, which may be one of its pharmacological mechanisms for lumbar intervertebral disc protrusion.