Objective To study the pharmacodynamic targets of quality markers of raw and processed Fructus Arctii, and to construct a "Component-Target-Disease" action network. Methods PharmMapper database was used to screen potential targets for six quality markers of raw and processed Fructus Arctii, STRING database was used to construct protein interaction network, and Cytoscape software was used to construct "Component-Target-Disease" network. Results Quality markers of raw and processed Fructus Arctii could play a role in anti-cancer, anti-inflammation, cardiac injury protection and anti-hypertension through multi-target action, and the related targets of each component were cross-linked to play a multi-target effect together. Conclusion The main pharmacodynamic effects of quality markers of raw and processed Fructus Arctii were revealed by network pharmacological method, which provided a scientific basis for further revealing the processing mechanism of Fructus Arctii.