In order to study the mechanical properties of interbedded rock composed of strongly weathered mudstone and sandstone in Urumqi subway tunnel, the micro-parameters of physical and mechanical parameters of interbedded rock mass are calibrated on the basis of obtaining physical and mechanical parameters of mudstone and sandstone in Urumqi. And then the response laws of mechanical properties of interbedded rock mass, under the action of thickness, thickness ratio, dip angle, both thickness ratio and dip angle of interbedded rock, are analyzed by uniaxial compression test of particle flow code numerical simulation. The results show that the layer thickness of the interbedded rock is negatively correlated with its uniaxial compressive strength. As the thickness ratio of the interbedded rock increases, the uniaxial compressive strength decreases and its gradient decreases gradually. With the increase of dip angle of the interbedded rock, the change of uniaxial compressive strength tends to be U-shaped, and the uniaxial compressive strength reaches the lowest when the rock dip angle is 40 The combination of dip angle and thickness ratio of interbedded rock has obvious influence on uniaxial compressive strength, and it is most obvious in the range of dip angle of interbedded rock 0、 20 and 80 and thickness ratio of interbedded rock is 0