Cyclic steam stimulation (CSS) is an important development method of heavy oil reservoir in China. Most blocks have entered the later stage of CSS, so the replacement of development method is considered urgently. In-situ combustion (ISC) is an available replacement method after CSS, and to study the potential adaptability of ISC is essential due to the high technique requirement. But the existing reservoir screening guide lags behind, and systematic screening methods have not been proposed, which are not suitable for the current ISC project. Therefore, it’s necessary to establish a reservoir screening method with better adaptability and reliability for ISC. In this regard, this paper summarizes the field examples and reservoir parameters at home and abroad based on a lot of investigations. Firstly, the reservoir type and development history of candidate reservoir are preliminarily screened. Secondly, the reservoir parameters are analyzed and evaluated by differential confidence method and grey correlation method to establish the reservoir parameter screen guide. Finally, the support vector machine method is selected to predict the development efficiency of ISC. Based on the above steps, a method of reservoir screening and evaluation for ISC is formed and applied to several blocks of Liaohe Oilfield to determine the suitable candidate blocks, which fulfilled the optimized evaluation of reservoir screening for ISC.