: To investigate the impact of stirrup configurations on the mechanical properties of reinforced concrete columns, the different stirrup configurations of columns as the main research parameters, four sets of reinforced concrete column specimens were designed. Reversed cyclic loading tests were conducted on each specimen to study the hysteretic curve, shear deformation, axial deformation, stiffness degradation, and energy dissipation coefficient. The results show that: encrypting the stirrups in the column can increase the maximum bearing capacity of specimens and control the degree of shear deformation and axial deformation before the failure of specimens; specifically, with the decreasing of the stirrup spacing in stirrups encryption area, the ductility and energy dissipation capacity of specimens increases. However, encrypting the stirrups on the column have no significant effect on the yield load, initial stiffness, second stiffness and stiffness degradation of specimens.