In order to study the effect of microwave ablation technique in different types of tumors, a microwave ablation model of coupled electromagnetic field and bioheat transfer process was established based on finite element simulation analysis method. The temperature distribution of white matter tumor, gray matter tumor, breast tumor , breast gland tumor, kidney tumor, lung tumor (inflated and uninflated state), liver tumor and muscle tumor in microwave ablation process were studied. The results show that due to the different physical properties of various types of tissue, the morphology of the microwave ablation antenna in different types of tumor tissue and the coverage of the effective damage area are significantly different. The ablation lesion formed in the breast cancer tumor surrounded by adipose tissue is in the shape of a drop, and the ablation area completely covers the tumor, but there is a trail along the direction of the ablation antenna; The ablation zone formed in the lung tissue in the uninflated state is greater than in the inflated state, The ablation zone formed in other parenchymal types of tissue is basically elliptical, the ablation zone as a whole is smaller than the lesions in the lungs and mammary glands. It can be seen that microwave ablation technology can obtain more effective therapeutic effects in ablation of breast and lung tumors.