In order to analyze the influence factors of fracture microwave-healing performance of asphalt mixtures, microwave heating test was carried out on bitumen and aggregates respectively. AC-13 semi-circular specimens were prepared with 70 # base asphalt and SBS modified asphalt, and fracture-healing-fracture test was carried out on specimens via semi-circular bending test and microwave heating. The ratio of tensile strength before and after healing loading test was used as healing index (HI). The microwave heating performance and effects of damage degree, microwave strength and heating time on self-healing performance of asphalt mixture were analyzed. The results show that microwave was mainly absorbed by aggregates, and through the heating and heat transfer of aggregate particles, the overall heating of the mixture is realized. The effect of microwave intensity on the self-healing performance is the most significant, followed by heating time. The self-healing ability of asphalt mixture increases with microwave intensity and heating time. The injury degree has a negative effect on self-healing performance, but the effect is weak.