Mengban lead-zinc mining area is located in Baoshan block in western Yunnan Province. The complex geotectonic activities in this area had laid favourable solid metallogenic foundation for the development of lead and zinc deposits, which also raised the difficulty on exploration of mineral resources. In order to further explore the prospects of mineral resources reserve in Mengban mining area, we found that the ore-bearing rock mass can observably generate induced polarization anomalies, based on the physical property analysis of rock (ore) samples and field test results. Therefore, several dual-frequency IP intermediate gradient profiles were deployed within the study area with 9 abnormal areas delineated, it resulted that five key prospecting targets have been determined by synthesizing the geochemical and geological data. Based on the above work, two IP Schlumberger sounding profiles were deployed in the key anomaly area to explore the deep vertical distribution and extension of the key anomaly body. This study provides a reference for the mineral exploration in Mengban area and its adjacent areas or similar areas, which is based on the study of the horizontal and vertical IP response characteristics in the mining area and supplemented by geological and geochemical exploration results.