The geometry of the door weather strip is decisive for the door seal. In this paper, based on the structural characteristics of the driving door seal of a certain vehicle, based on the domestic independent CAE software HAJIF, the research on the influence of the geometric design parameters of the weather strip on the sealing performance is carried out. Firstly, the soft rubber section parameters of the driving door seal are selected as the design variables for the sensitivity analysis, the relationship between the contact pressure and the geometric section parameters, and then the geometry design improvement of the weather strip configuration based on the analysis results is given. The design required for the project. The analysis and design results of this paper provide a reference for the design of the sealing strip product, which can help the research and development personnel to develop the door sealing system.