In order to accurately predict the dynamic resilient modulus of different working areas of heavy haul railway subgrade，the dynamic triaxial loading sequence was redesigned. Then, the dynamic triaxial sequence loading test under different water content and different degrees of compaction was carried out. The factors influencing the dynamic resilient modulus are analyzed, and the predictive model is used to perform regression analysis on the dynamic resilient modulus. The results show that the dynamic resilient modulus decreases with the increase of the amplitude of the dynamic stress, and the average reduction rate is 9.77%. The dynamic resilient modulus increases with the increase of confining pressure, and the average growth rate is 16.16%. The change of soil moisture content and dry density will cause the dynamic resilient modulus to change. When the dynamic stress amplitude is large, the dynamic resilient modulus will change to a linear change. In addition, the Ni model considering the dynamic stress and confining pressure has a good correlation with the test results, which can provide theoretical basis and empirical parameters for the design of heavy-duty railway subgrade.