In order to study the uniaxial mechanical properties and failure modes of thermo-liquid coupled granite, the thermo-liquid coupling cycle treatment of granite under different temperatures was carried out, and the variation of mechanical characteristics was analyzed by uniaxial compression test. The results show that: (1) The peak intensity increases with increasing temperature. The peak intensity decreases by 11.51% When the temperature is in the range of 50-100 °C,the peak intensity is reduced by 1.77% when temperature is in the range of 100-150 °C; The peak strain is linearly related to the cycle temperature, it decreases as the temperature increases; The modulus of elasticity increases first and then decreases with increasing temperature, and the increase is about 123.21%. (2) As the number of cycles increases, there are different changes in peak intensity, it was slowly changed before 3 cycles, the peak intensity is reduced by 19.87% when the cycle is 3-4 times , the peak intensity is reduced by 22.70% when the cycle is 4-5 times ; The peak strain has a polynomial fit with the number of cycles, the peak intensity is maximum when 3 cycles, The elastic modulus has a polynomial fit with the number of cycles, the elastic modulus is Minimum when 3 cycles . (3) In the contour plot, the peak intensity is symmetrically distributed in 3 cycles at a temperature interval of 50-100 ° C; The peak strain decreases as the cycle temperature increases and the number of cycles increases, In the contour map, the elastic modulus exhibits a bimodal mode, and the modulus of elasticity increases as the temperature increases and the number of cycles increases. (4) The stress-strain curve undergoes four stages of compaction, elasticity, yielding and failure, and brittle failure occurs. Destruction is divided into splitting and shearing. It is concluded that the thermo-liquid coupling has a certain influence on the mechanical properties of granite.