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马青青. 肥胖低通气综合征患者血清瘦素水平的变化及意义[J]. 科学技术与工程, 2020, 20(1): 118-122.
ma qing qing.Changes and Significance of Serum Leptin Levels in Patients with Obesity Hypoventilation Syndrome[J].Science Technology and Engineering,2020,20(1):118-122.
肥胖低通气综合征患者血清瘦素水平的变化及意义
Changes and Significance of Serum Leptin Levels in Patients with Obesity Hypoventilation Syndrome
投稿时间:2019-04-23  修订日期:2019-09-20
DOI:
中文关键词:  肥胖低通气综合征 阻塞性睡眠呼吸暂停 体重指数 血清瘦素 动脉血气分析
英文关键词:obesity hypoventilation syndrome obstructive sleep apnea body mass index serum leptin arterial blood gas analysis
基金项目:
  
作者单位
马青青 徐州医科大学附属医院呼吸内科
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中文摘要:
      为了研究血清瘦素在肥胖低通气综合征(OHS)患者体内的变化及其意义,通过酶联免疫吸附测定(ELISA)、多导睡眠图监测等方法研究了OHS患者血清瘦素水平,选取OHS组23例、不伴有OHS的肥胖OSA患者40例(肥胖OSA组)、不伴肥胖OSA患者14例(非肥胖OSA组)、单纯性肥胖者6例(单纯肥胖组)和健康成人10例(正常对照组)。比较所有研究对象性别、年龄、颈围、腰围、BMI等一般资料、血清瘦素水平和多导睡眠参数,对OHS组、肥胖OSA组、单纯肥胖组行血气分析,并对其结果进行比较。对瘦素与其他相关参数进行相关性分析,并分析瘦素等指标对OHS的诊断预测。结果表明OHS组BMI[(42.6±8.7)kg/m2,P<0.05]、颈围[(45.5±4.7) cm,P<0.05]较其他组明显升高,单纯肥胖组的患者年龄较其他组更小[(30±11) 岁,P<0.05]。OHS组血清瘦素水平[(14.4±1.1)ng/mL]显著高于肥胖OSA组[(11.9±0.8)ng/mL,P<0.05]、单纯性肥胖组 [(9.3±0.9) ng/mL,P<0.05) ]、非肥胖OSA组[(10.8±0.9) ng/mL,P<0.05]和正常对照组 [7.0±0.7) ng/mL,P<0.05) ],且各组之间均存在显著性的差异(P<0.05)。血清瘦素水平与BMI(r=0.38,P<0.01)、颈围(r=0.35,P<0.01)、腰围(r=0.37,P<0.01)、臀围(r=0.38,P<0.01)、PaCO2 (r=0.59,P<0.01) 、动脉血HCO3- (r=0.48,P<0.01) 和静脉血HCO3- (r=0. 29,P<0.01) 呈正相关,与PaO2(r=-0.45,P<0.01)呈负相关。BMI、颈围、腰围和血清瘦素水平对OHS具有诊断预测作用。可见OHS患者中血清瘦素水平较肥胖OSA组、单纯肥胖组明显升高,除了肥胖因素外,OHS本身也可成为血清瘦素水平升高的原因,血清瘦素水平的升高可以作为OHS的诊断预测指标之一。
英文摘要:
      In order to study the change and significance of serum leptin in obese hypoventilation syndrome (OHS) patients. Serum leptin levels in patients with OHS were studied by enzyme-linked immunosorbent assay (ELISA) and polysomnography.Choose 23 patients in the OHS group, 40 patients with obesity OSA without OHS (obese OSA group), 14 patients without obesity OSA (non-obese OSA group), and simple obesity were selected. 6 cases (simple obesity group) and healthy adults 10 cases (normal control group). The gender, age, neck circumference, waist circumference, BMI and other general data, serum leptin levels and polysomnography parameters were compared among all subjects. Blood gas analysis was performed in OHS group, obese OSA group and simple obesity group, and the results were compared. Correlation analysis of leptin and other related parameters, and analysis of the diagnostic prediction of OHS by indicators such as leptin. The results show that the BMI of the OHS group [(42.6±8.7) kg/m2, P<0.05] and the neck circumference [(45.5±4.7) cm, P<0.05] were significantly higher than the other groups. Younger than other groups [(30 ± 11) years old, P < 0.05]. The serum leptin level in the OHS group [(14.4±1.1) ng/mL] was significantly higher than that in the obese OSA group [(11.9±0.8) ng/mL, P<0.05], and the simple obesity group [(9.3±0.9) ng /mL, P<0.05)], non-obese OSA group [(10.8±0.9) ng/mL, P<0.05] and normal control group [7.0±0.7) ng/mL, P<0.05) There was a significant difference between the groups (P < 0.05). Serum leptin levels and BMI (r=0.38, P<0.01), neck circumference (r=0.35, P<0.01), waist circumference (r=0.37, P<0.01), hip circumference (r= 0.38, P<0.01), PaCO2 (r=0.59, P<0.01), arterial blood HCO3- (r=0.48, P<0.01) and venous blood HCO3- (r=0.29,P <0.01) was positively correlated and negatively correlated with PaO2 (r=-0.45, P<0.01). BMI, neck circumference, waist circumference and serum leptin levels have diagnostic predictive effects on OHS. It is concluded that serum leptin levels in OHS patients are significantly higher than those in obese OSA group and simple obesity group. In addition to obesity, OHS itself can also be a cause of elevated serum leptin levels,Increased serum leptin levels can be used as one of the diagnostic predictors of OHS.
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