Clock synchronization is a key technology in wireless distributed systems. In order to compensate the offset error caused by the dynamic change of the link data rate in the wireless network and improve the clock synchronization accuracy, this paper proposes an asymmetric wireless transmission IEEE 1588 clock synchronization algorithm based on dynamic change. The algorithm calculates the clock offset error of the master and slave nodes based on the asymmetry ratio of the dynamically changing wireless link. The simulation results show that the offset error of the slave clock can be reduced to 10-3 μs. The application of this algorithm in wireless networks can significantly improve the clock synchronization accuracy.