In order to determine drivers’ vehicle control ability on S-curve influenced of foggy weather,46 drivers were selected for simulation driving experiment on S-curve of foggy weather.MANOVA and chi-square test were carried out on the test data of straight line stage, transitional stage and curve stage to analyze the effects of fog, driving experience and gender on driving speed, deceleration distance and departure times. The results shows that visibility conditions have significant effects on vehicle control ability in all three stages,especially the influence in the transitional stage,is the most obvious. There are significant differences in the deceleration distance, and departure times of drivers. Professional drivers tend to be more cautious than non-professional drivers in the process of curve passing. The control ability of female drivers in curve driving is significantly lower than that of male drivers, and non-professional female drivers are the most vulnerable group in curve driving.