The dynamic differential equation of a wheel drive electric vehicle is deduced. And the ride comfort simulation model of 1/4 vehicle is established in MATLAB/Simulink. Taking the body vibration acceleration and the dynamic load as evaluation indexes, the ride comfort performance of the wheel drive vehicle is compared with the dynamic vibration absorbing wheel drive electric vehicle under the New European Driving Cycle (NEDC) condition. Taking the Minimum value of maximum vibration displacement of wheel as the objective function, the parameters of suspension and absorber for dynamic vibration absorbing wheel drive electric vehicle are optimized, and the comparative simulation is carried out. The simulation results show that: for the dynamic vibration absorbing wheel drive electric vehicle, the root mean square value of body vibration acceleration is decreased by 8.2%, the root mean square value of the dynamic load is reduced by 0.12%, which obviously improves the ride comfort performance of the vehicle and has certain guiding significance for improving the ride comfort performance of the wheel drive electric vehicle.