Tailings storehouse is the most important project of mine-enterprise, and the dam-break by the poor stability is a serious disaster. In this paper, the effective stress method without drainage is applied to the seismic response analysis of the Zhelamujing tailing dam, and the dynamic safety factor of the tailing dam is calculated. The results indicated that the safety factor meet regulatory requirements, and Zhelamujing tailing dam is stable under 8-degree earthquake. The results provided references to evaluation method for stability analysis of tailings dam.