Objective To study the efficacy of nicergoline through a few different deliveries in treatment of thrombosis in rat. Methods Uses the method of the formation of artery-vein thrombus in rat, then estimates the formation of thrombus suppression rate. Results All of deliveries of Nicergoline can suppress the formation of thrombus in rat obviously, sorts for the deliveries absorption's speed is differently: Injection vein> nasal administration >sublingual administration. Conclusion The nasal administration of Nicergoline had the same effect as to injection vein, so we can thought that the nasal deliveries would absord well in human’s body.